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While MRI can detect brain swelling/compression and CT can detect brain bleeding, neither type of scanner can find small traumatic brain lesions involving torn axons. So many mild and some moderate traumatic brain injuries remain invisible. However, a team of researchers at UC San Diego is making use of a new high tech
NeuroVive Pharmaceutical, AB is a Swedish drug development company. Working with NeuroStat it has developed a mechanism for delivering drugs directly to the brain through the blood-brain-barrier which normally screens out large molecules. In recent tests NeuroVive has shown that cyclosporine A, a drug used to help organ transplant recipients avoid immune rejection,
Some of the soldiers returning from Iraq and Afghanistan with TBI are displaying the dual problem of seizures and migraine. Two University of Utah researchers (K.C. Brennan, M.D., assistant professor of Neurology, and Edward Dudek, Ph.D., professor and chair of the Department of Physiology) are teaming up with the Department of Defense to
Benjamin Cravatt, Ph.D., at the Scripps Research Institute and Daniel Nomura, Ph.D., at UC Berkeley have made an important discovery about how to block brain inflammation, something which can severely compound the initial damage done by a TBI. They learned that in the brain the production of arachidonic acid (which gets converted into
Lithium has been used for decades to treat mania. Psychiatrists believe that lithium controls mania in part by decreasing the activity of the excitatory neurotransmitter glutamate. Following TBI some brain cells release excessive quantities of glutamate which damages or kills other brain cells. Fengshan Yu and colleagues at NIH and the University of
Steven Flanagan, M.D., Chairman of the Department of Rehabilitation Medicine at the NYU’s Rusk Medical Institute is an expert on rehabilitation of adult and child traumatic brain injuries. In December 2011 he will give a talk in Orlando, Florida, offering a rationale for treating TBI as a chronic disease with long-lasting medical problems
Mark Gordon, M.D. is an American physician who pioneered the recognition and treatment of hormonal deficiency caused by TBI. According to Dr. Gordon any TBI (mild, moderate or severe) can dysregulate a person’s hormones leading to increased risk of emotional instability, drug and alcohol abuse, depression, anxiety, mood swings, memory loss, fatigue, confusion,
The conclusion of a 35-year Swedish population study published in the December 27, 2011 online issue of PLOS Medicine was that TBI, but not epilepsy, increases the risk of violent crime. Researchers from the Centre for Violence Prevention at Sweden’s Karolinska Institute combined Swedish population registers from 1973 to 2009, and examined associations
Mitchondria are the energy producing component of brain cells that fuel brain cell activity. Following TBI excessive release of the neurotransmitter glutamate can kill mitochondria by causing toxic influx of calcium into brain cells. A new treatment approach involving IV infusion of a drug called a mitochondria-uncoupler has been found to protect mitochondria
In January 2012 Maria-Victoria Gomez-Gaviro and Dr Robin Lovell-Badgehave published an article in the Proceedings of the National Academy of Sciences about the potential for a cord blood protein called Betacellulin to boost brain tissue regneration following TBI. The human brain and mouse brain share niches filled with stem cells that can produce
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